Search results for " Islet Cell"
showing 6 items of 6 documents
Value of Quantitative DNA Analysis in Endocrine Tumors of the Pancreas
1997
The diagnosis of malignancy can be difficult in endocrine tumors of the pancreas. Moreover prognostically relevant factors are not available. The aim of this study was to evaluate retrospectively whether the DNA distribution pattern can differentiate between benign and malignant pancreatic endocrine tumors and secondly whether the DNA content of tumor cells gives prognostic information.Image cytometry of paraffin-embedded tumor material of 42 pancreatic endocrine tumors.In 27 benign endocrine pancreatic tumors (25 insulinomas, 2 benign nonfunctioning endocrine tumors) we could differentiate between 6 diploid, 15 hypotriploid and 6 triploid DNA histograms. In 15 malignant endocrine tumors of…
Exenatide prevents statin-related LDL receptor increase and improves insulin secretion in pancreatic beta cells (1.1E7) in a protein kinase A-depende…
2022
Statins are primary drugs in the treatment of hyperlipidemias. This group of drugs is known for its beneficial pleiotropic effects (e.g., reduction of inflammatory state). However, a growing body of evidence suggests its diabetogenic properties. The culpable mechanism is not completely understood and might be related to the damage to pancreatic beta cells. Therefore, we conceived an in vitro study to explore the impact of atorvastatin on pancreatic islet beta cells line (1.1.E7). We evaluated the influence on viability, insulin, lowdensity lipoprotein (LDL) receptor, and proprotein convertase subtilisin/kexin type 9 (PCSK9) expression. A significant drop in mRNA for proinsulin and insulin e…
ERCP and MRCP in the Differentiation of Pancreatic Tumors
2004
The introduction of endoscopic retrograde cholangiopancreatography (ERCP) in the early 1970s provided gastroenterologists with a number of diagnostic as well as therapeutic possibilities for examining biliopancreatic systems. In the meantime, magnetic resonance cholangiopancreatography presents a non-invasive alternative to diagnostic ECRP providing the advantage of a lower rate of possible complications. This article addresses the two methods presently available for differentiating pancreatic tumors. The objective of this article is to describe the advantages and disadvantages as well as the possibilities inherent in both methods.
Ultrasonic demonstration of small pancreatic islet cell tumors.
1982
In three patients real-time sonography successfully localized small pancreatic islet cell tumors measuring 7, 8, and 17 mm in size. Ultrasound is suggested as the initial radiologic examination for localization of endocrine pancreatic tumors. If ultrasound is negative or equivocal, computerized tomography, arteriography, and pancreatic venous sampling are indicated.
Role of ghrelin and leptin in the regulation of carbohydrate metabolism. Part I. Ghrelin
2012
Grelina jest polipeptydem wydzielanym przez komórki wydzielnicze błony śluzowej żołądka i jelit, jądro łukowate podwzgórza, a także przez komórki epsilon (e), które znajdują się w obrębie wysp trzustkowych. Grelina odgrywa ważną rolę w utrzymywaniu homeostazy energetycznej organizmu oraz wpływa na wewnątrzwydzielniczą funkcję trzustki i metabolizm glukozy. W regulacji homeostazy glukozy grelina bierze udział poprzez modulację wydzielania isuliny, jak i wrażliwości na insulinę. Wobec różnorodnych biologicznych skutków działania greliny, obecne badania poświęca się potencjalnym możliwościom ich modyfikowania. Dużo uwagi skupiono wokół enzymu zwanego O-acylo transferazą greliny (ghrelin O-acyl…
Localization of small islet-cell tumors. Preoperative and intraoperative ultrasound, computed tomography, arteriography, digital subtraction angiogra…
1985
A total of 42 islet-cell tumors were examined between 1972 and 1984. Problems of localization were only encountered in 31 tumors less than 2 cm in diameter. Of 31 small tumors, 27 were correctly localized using a combined diagnostic approach: ultrasound was successful in 12/20 tumors, CT in 9/21, angiography in 20/31, intraarterial digital subtraction angiography in 1/2, and pancreatic venous sampling in 13/16. The smallest tumor found by ultrasound and CT was 7 mm in diameter. Intraoperative ultrasound demonstrated all 9 insulinomas examined. Currently, the most useful techniques for localizing small islet-cell tumors are ultrasound, CT, and angiography. CT is particularly useful for tumor…